Experimentell karakterisering av den humana icke-sekvensspecifika


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DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4 UniProt builds upon the solid foundations laid by the consortium members PIR, European Bioinformatics Institute and Swiss Institute of Bioinformatics over many years. When to use UniProt Use UniProt to retrieve Ku70 autoantigen PIRSF016570:Ku80 autoantigen PIRSF Homeomorphic Family • Exactly one level • Full-length sequence similarity Ku70/80 subunits PF02735: Ku70/Ku80 beta- barrel domain Domain Superfamily • One common Pfam domain PIRSF006493: Ku DNA-binding protein, prokaryotic type PIRSF016570: Ku DNA-binding complex, Ku80 subunit PIRSF500001: IGFBP-1 pir.georgetown.edu/pirsf pir.georgetown.edu/iprolink Ku70 was detected in paraffin-embedded section of Human Tonsil Tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/ml rabbit anti-Ku70 Antibody (PB9520) overnight at 4°C.

Ku70 uniprot

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Genom att surfa vidare godkänner du att vi använder kakor. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA (By similarity). Ku70 and Ku80 have also been experimentally characterized in plants, where they appear to play a similar role to that in other eukaryotes. In rice, suppression of either protein has been shown to promote homologous recombination (HR) [13] This effect was exploited to improve gene targeting (GT) efficiency in Arabidopsis thaliana .

Ku protein - Ku protein - qaz.wiki

X-ray repair cross complementing 6 [Source:HGNC Symbol;Acc: HGNC:4055]. Gene Synonyms. D22S671, D22S731, G22P1, KU70, ML8. Location. Recombinant Human Ku70 protein is a Wheat germ Full length protein 1 to 609 aa range and validated in WB, ELISA, SDS-PAGE.

Ku70 - Ku70 - qaz.wiki

Ku70 is involved in repair of  G22p1, Ku70, Ku p70 less. UniProt. 6 Sequences. Protein Ontology. PR: 000017509 X-ray repair IPR027388 Ku70, bridge and pillars domain superfamily. UniProt Comments for Ku P70/P80. Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication.

Ku70 uniprot

Ku70 is the 70 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80.
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Belongs to the ku70 family. (Q23976).

Ku70 är ett känt Sirt1-underlag, vilket indikerar att målreglering av olika sirtuins kan A homology model for human Sirt1 residues 214–497 (UniProt entry  tvärkompletterande protein 6 (XRCC6, även känd som Ku70), förutsagd som UniProt Q9UFW8) hade starka DNA- och C- och G-rika nukleotidpreferenser  InteraktionerRedigera. Werner syndrom ATP-beroende helikas har visat sig interagera med: BLM; DNA-PKcs ,; FEN1 ,; Ku70 ,; Ku80 ,; P53 ,; PCNA ,; TERF2 ,​  KU70 - ATP-dependent DNA helicase 2 subunit KU70 - Arabidopsis thaliana (Mouse-ear cress) - KU70 gene & protein UniProtKB - Q9FQ08 (KU70_ARATH) Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase.
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P38 mapk-signalering och fosforyleringar i brct1-domänen

Final Ku70 vWA candidates are shared with full-length Ku70 results and absent from the Ku70 vWA protein candidates list. Final candidates were filtered using the negative control cell lines, HEK293 and NLS-BioID2. Uniprot Id: P12956: NCBI Gene Id: 2547: Species Of This Entry: Human: Gene Name: XRCC6: Protein Name: X-ray repair cross-complementing protein 6: Superfamily: ku70 family Invitrogen Anti-Ku70 Polyclonal, Catalog # PA5-25915. Tested in Western Blot (WB), Immunohistochemistry (Paraffin) (IHC (P)) and Flow Cytometry (Flow) applications. This antibody reacts with Human, Mouse samples. Supplied as 400 µL purified antibody (2 mg/mL).